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Heregulin-β1, Human, Recombinant
貨號：PCK373
價格：￥78018801188016880
規(guī)格：
10μg
- 10μg
- 50μg
- 500μg
- 1mg
產(chǎn)品概述
產(chǎn)品信息
| 別名 | Pro-neuregulin-1, Neuregulin-1 beta 1, NRG1-beta 1, HRG1-beta 1, EGF, NRG1, GGF, HGL, HRGA, NDF, SMDF, Heregulin-β1 |
| 物種 | Human |
| 表達宿主 | E.coli |
| 序列信息 | A DNA sequence encoding Human Heregulin Beta 1 Protein (#Q02297-6) (Ser177-Glu241) was expressed with polyhistidine tag at the C-terminus. |
| 檢索號 | Q02297-6 |
| 分子量 | 8.42 kDa |
| 表觀分子量 | 8 kDa |
| 標簽 | His Tag (C-term) |
| 生物活性 | Measure by its ability to induce MCF-7 cells proliferation. The ED?? for this effect is < 10 ng/mL. |
產(chǎn)品特性
| 純度 | >95% as determined by SDS-PAGE. Ni-NTA chromatography. |
| 內(nèi)毒素 | <0.1 EU per 1 μg of the protein by the LAL method. |
| 保存 | Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution, store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1% BSA, 10% FBS, 5% HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months. |
| 運輸 | Ambient temperature or ice pack. |
| 制劑 | The protein was lyophilized from a 0.2 μm filtered solution containing 1 × PBS, pH8.0. |
| 復融 | It is recommended to reconstitute the lyophilized protein in sterile water to aconcentration not less than 100 μg/mL. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein. |
背景介紹
Neuregulin-1 (NRG-1, also called heuregulin1 or neu differentiation factor) is a glycoprotein that belongs to the neuregulins family. Structurally, Neuregulin-1 harbors tissue-speci?c N terminal sequence, followed by immunoglobulin-like (Ig-like) domains, an EGF-like domain, a transmembrane domain, and a cytoplasmic domain. NRG1 has multiple isoforms produced by alternative splicing. Heregulin-β1 (HRG-β1) is one of the isoforms, has been reported to engage the development and survival of cardiomyocytes derived from embryonic stem (ES) cells via activating MAPK-ERK and PI3K-AKT pathways. Moreover, HRG-β1 plays a central role in promoting the proliferation of neuronal progenitors from embryonic neural stem cells.
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