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RANK L/ TRANCE/ TNFSF11 (N-6His), Mouse, Recombinant
貨號(hào)：PCK061
價(jià)格：￥1780￥4980￥17480￥27980
規(guī)格：
10μg
- 10μg
- 50μg
- 500μg
- 1mg
產(chǎn)品概述
產(chǎn)品信息
| 別名 | Tumor necrosis factor Ligand superfamily member 11; Tnfsf11; Osteoclast differentiation factor; ODF; Osteoprotegerin Ligand; OPGL; Receptor activator of nuclear factor kappa-B Ligand; RANKL; TNF-related activation-induced Cytokine; TRANCE; CD254 |
| 物種 | Mouse |
| 表達(dá)宿主 | Human Cells |
| 序列信息 | Arg43-Asp287 |
| 檢索號(hào) | BAA97257.1 |
| 分子量 | 28.3kDa |
| 表觀分子量 | 30-35 kDa |
| 標(biāo)簽 | N-6His |
| 生物活性 | Loaded Recombinant Human OPG-Fc on Pro A Biosensor, can bind Mouse RANKL-His with an affinity constant of 1.02 pM as determined in BLI assay. |
產(chǎn)品特性
| 純度 | >90% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運(yùn)輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of 20mM Hepes-NaOH, 50mM NaCl, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 8.0. |
| 復(fù)融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
Mouse tumor necrosis factor Ligand superfamily member 11 (Tnfsf11) is a member of the tumor necrosis factor (TNF) Cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This Cytokine can bind to TNFRSF11B/ OPG andTNFRSF11A/ RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
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