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pro-BDNF/ BDNF, Human, Recombinant
貨號：PCK084
價格：￥1380￥3680￥17480￥25680
規(guī)格：
10μg
- 10μg
- 50μg
- 500μg
- 1mg
產(chǎn)品概述
產(chǎn)品信息
| 別名 | Brain-Derived Neurotrophic Factor; BDNF; Abrineurin |
| 物種 | Human |
| 表達(dá)宿主 | E.coli |
| 序列信息 | Ala19-Arg247(R125A,R127A,R128A) |
| 檢索號 | P23560 |
| 分子量 | 25.6 kDa |
| 表觀分子量 | 28 kDa |
產(chǎn)品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C,stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 運輸 | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
| 制劑 | Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 100mM NaCl, 0.02% Tween 80, pH 6.0. |
背景介紹
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin Receptor p75 (p75NTR) and vps10p domain-containing Receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase Receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
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