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ACVR2A (C-6His), Human, Recombinant
一鍵復(fù)制產(chǎn)品信息

貨號：PCK106

價格：￥980￥2480￥17480￥25680

規(guī)格：

10μg

10μg
50μg
500μg
1mg

數(shù)量： - +

說明書

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產(chǎn)品概述

產(chǎn)品信息

別名	Activin Receptor Type-2A; Activin Receptor Type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2
物種	Human
表達(dá)宿主	Human Cells
序列信息	Ala20-Pro134
檢索號	P27037
分子量	14.35 kDa
表觀分子量	28-38 kDa

產(chǎn)品特性

純度	>95% as determined by reducing SDS-PAGE.
內(nèi)毒素	<1.0 EU per μg as determined by LAL test.
保存	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C,stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
運(yùn)輸	Ambient temperature or ice pack.
制劑	Supplied as a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, 10% Glycerol, 5% Trealose, pH7.4.

背景介紹

Activin Receptor Type-2A is a Protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activintype 2 Receptor. This gene encodes activin A type II Receptor. Activins are dimeric growth anddifferentiation factors which belong to the transforming Growth Factor-beta (TGF-beta) superfamily ofstructurally related signaling Proteins. Activins signal through a heteromeric complex of Receptor serinekinases which include at least two type I (I and IB) and two type II (II and IIB) Receptors. These Receptors areall transmembrane Proteins, composed of a Ligand-binding extracellular domain with cysteine-rich region, atransmembrane domain, and a cytoplasmic domain with predicted serine/ threonine specificity. Type IReceptors are essential for signaling; and type II Receptors are required for binding Ligands and forexpression of type I Receptors. Type I and II Receptors form a stable complex after Ligand binding, resultingin phosphorylation of type I Receptors by type II Receptors. Type II Receptors are considered to beconstitutively active kinases.