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IL-1R-2/ CD121b (C-Fc), Human, Recombinant
貨號：PCK146
價(jià)格：￥1280￥2980￥17480￥25680
規(guī)格：
10μg
- 10μg
- 50μg
- 500μg
- 1mg
產(chǎn)品概述
產(chǎn)品信息
| 別名 | Interleukin-1 Receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II Receptor; Interleukin-1 Receptor beta; IL-1R-beta; Interleukin-1 Receptor type II; CD121b |
| 物種 | Human |
| 表達(dá)宿主 | Human Cells |
| 序列信息 | Phe14-Glu343 |
| 檢索號 | P27930 |
| 分子量 | 64.5 kDa |
| 表觀分子量 | 80-95 kDa |
| 標(biāo)簽 | C-Fc |
產(chǎn)品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運(yùn)輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 復(fù)融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
Interleukin-1 Receptor type 2 (IL1R2) belongs to the Interleukin-1 Receptor family. Two distinct types of IL1 Receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 Receptor type II is a 68 kDa transmembrane Protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling Receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy Receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/ soluble Receptors.
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