產(chǎn)品中心Cell Resources
聯(lián)系我們CONTACT US
400-999-210024小時服務(wù)熱線
IL-36α, Human, Recombinant
貨號：PCK194
價格：￥1780￥4980￥17480￥25680
規(guī)格：
10μg
- 10μg
- 50μg
- 500μg
- 1mg
產(chǎn)品概述
產(chǎn)品信息
| 別名 | Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6 |
| 物種 | Human |
| 表達(dá)宿主 | E.coli |
| 序列信息 | Lys6-Phe158 |
| 檢索號 | Q9UHA7 |
| 分子量 | 17.1 kDa |
| 表觀分子量 | 17 kDa |
| 生物活性 | Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 1.83 ng/ml. |
產(chǎn)品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 6% Trehalose, 5mM EDTA, 0.05% Tween 80, pH7.4. |
| 復(fù)融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
Human Interleukin-36α (IL-36α) is a secreted Cytokine that belongs to the Interleukin 1 Cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this Cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding Receptor which upon ligation, recruits a second Receptor as a signaling component, forming an active heterodimeric Receptor complex.
FAQs
Q：{{item.question}}
A：
暫無數(shù)據(jù)
產(chǎn)品資料
注：百度瀏覽器無法支持掃一掃功能，請輸入識別碼，獲取相應(yīng)產(chǎn)品資料
識別碼示意圖
