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IL-4Rα/ CD124 (C-mFc), Human, Recombinant
貨號(hào)：PCK198
價(jià)格：￥1380￥3680￥17480￥25680
規(guī)格：
10μg
- 10μg
- 50μg
- 500μg
- 1mg
產(chǎn)品概述
產(chǎn)品信息
| 別名 | Interleukin-4 Receptor subunit alpha; IL-4 Receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding Protein; IL4-BP; IL4R; IL4RA |
| 物種 | Human |
| 表達(dá)宿主 | Human Cells |
| 序列信息 | Met26-Gln231 |
| 檢索號(hào) | P24394 |
| 分子量 | 50.2 kDa |
| 表觀分子量 | 65-86 kDa |
| 生物活性 | Loaded Human IL-4-His on HIS1K Biosensor, can bind Human IL-4RA-mFc with an affinity constant of 0.12 nM as determined in BLI assay. |
產(chǎn)品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運(yùn)輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
| 復(fù)融 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glyco Protein in theclass I Cytokine Receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellulardomain (ECD) that contains a Cytokine binding region and one fibronectin type III domain, a 24 aatransmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 Motif and one ITIMMotif. IL4-Ra plays an important role in Th2-biased immune responses, alternative macrophage activation,mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Soluble forms of IL4-Ra,generated by alternate splicing or proteolysis, retain Ligand binding properties and inhibit IL-4 bioactivity.
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