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BMP-2/LEM/MCF, Human, Recombinant
貨號(hào)：PCK273
價(jià)格：￥980￥￥￥
規(guī)格：
10μg
- 10μg
產(chǎn)品概述
產(chǎn)品信息
| 別名 | Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) |
| 物種 | Human |
| 表達(dá)宿主 | E.coli |
| 序列信息 | MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR with polyhistidine tag at the C-terminus |
| 檢索號(hào) | P12643 |
| 分子量 | 13.76 kDa |
| 表觀分子量 | 14 kDa |
| 標(biāo)簽 | His-tag?at?the?C-terminus |
| 生物活性 | Measure by its ability to induce alkaline phosphatase production by ATDC5 cells.The ED50 for this effect is <9.5 ng/mL.The specific activity of recombinant BMP-2 is > 3.2 x 10^6IU/mg. |
產(chǎn)品特性
| 純度 | >95% as determined by SDS-PAGE. Ni-NTA chromatography. |
| 內(nèi)毒素 | <0.1 EU per 1 μg of the protein by the LAL method. |
| 保存 | Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution, store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1%BSA,10%FBS,5%HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months. |
| 運(yùn)輸 | Ambient temperature or ice pack. |
| 制劑 | The protein was lyophilized from a 0.2 μm filtered solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5. |
| 復(fù)融 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL.Do Not Vortex! Vigorous shaking may impair the biological activity of the protein. |
背景介紹
BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition. Like many other proteins from the BMP family, BMP-2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2 may be involved in white adipogenesis and may have metabolic effects.
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