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TGF-β1, Human, Recombinant
一鍵復(fù)制產(chǎn)品信息

貨號：PCK091

價格：￥1780￥4980￥24080￥35580

規(guī)格：

10μg

10μg
50μg
500μg
1mg

數(shù)量： - +

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產(chǎn)品概述

產(chǎn)品信息

別名	Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB
物種	Human
表達宿主	CHO Stable Cells
序列信息	Ala279-Ser390
檢索號	P01137
分子量	12.8 kDa
表觀分子量	13 kDa
生物活性	Measured by its ability to inhibit the IL-4-dependent proliferation of TF?1 human erythroleukemic cells. The ED50 for this effect is 4-40 pg/ml.

產(chǎn)品特性

純度	>95% as determined by reducing SDS-PAGE.
內(nèi)毒素	<1.0 EU per μg as determined by LAL test.
保存	Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
運輸	Ambient temperature or ice pack.
制劑	Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mMNacl, pH2.5.
復(fù)融	Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介紹

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.

參考文獻

文獻列表

miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury(2019/7/3)

作者：Zilun Wei, Shuaihua Qiao, Jinxuan Zhao

期刊：Life Sciences

DOI：10.1016/j.lfs.2019.116632

影響因子：6.100

引用產(chǎn)品：PCK091
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) activates p38 to affect pulmonary fibrosis(2024/05/17)

作者：Yan An, Suyan Yan, Wei Xu

期刊：Regenerative Therapy

DOI：10.1016/j.reth.2024.05.002

影響因子：4.300

引用產(chǎn)品：PCK091
High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT(2024/05/16)

作者：Shijing You, Xiahui Han, Yuance Xu

期刊：Cancer Medicine

DOI：10.1002/cam4.7217

影響因子：4.000

引用產(chǎn)品：PCK091
The silencing of lnc-NONHSAT071210 suppresses the proliferation, fibrosis, migration, and invasion of TGFβ1-treated lung epithelial cells(2022/11/01)

作者：Yuan Liu, Fuai Lu, Xiaofen Li

期刊：Annals of Translational Medicine

DOI：10.21037/atm-22-5223

影響因子：3.616

引用產(chǎn)品：PCK091
SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 Axis(2021/7/21)

作者：Wang Yao, Siqi Wang, Xing Du

期刊：Reproductive Sciences

DOI：10.1007/s43032-021-00690-4.

影響因子：2.900

引用產(chǎn)品：PCK091
DNMT3B attenuated the inhibition of TET3 on epithelial-mesenchymal transition in TGF-β1-induced ovarian cancer by methylating the TET3 promoter(2022/10/12)

作者：Zhongxue Ye, Yafen Jiang, Junlong Wu

期刊：Reproductive Biology

DOI：10.1016/j.repbio.2022.100701

影響因子：2.100

引用產(chǎn)品：PCK091