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產(chǎn)品概述
| 名稱 | TM4 (正常小鼠睪丸Sertoli細(xì)胞) (STR鑒定正確) |
| 別稱 | TM-4 |
| 種屬 | 小鼠 |
| 生長(zhǎng)特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 注意事項(xiàng) | 該細(xì)胞貼壁松散，操作時(shí)請(qǐng)盡量輕柔；換液時(shí)需預(yù)熱培養(yǎng)基；收貨如有大塊脫落的細(xì)胞團(tuán)，為正?，F(xiàn)象，請(qǐng)按照收貨注意事項(xiàng)處理。 |
| 背景描述 | TM4細(xì)胞在FSH的作用下cAMP產(chǎn)量增加，但對(duì)LH無(wú)反應(yīng)；TM4細(xì)胞與原代Sertoli細(xì)胞相比，對(duì)FSH的反應(yīng)性降低。據(jù)報(bào)道，TM4細(xì)胞組成性纖溶酶原激活物的產(chǎn)量很低，但可被FSH刺激產(chǎn)生，受維甲酸刺激可有大幅增高。TM4細(xì)胞可產(chǎn)生視黃醇結(jié)合蛋白、組織纖溶酶原激活物和轉(zhuǎn)鐵蛋白；TM4細(xì)胞表達(dá)FSH受體、雄激素受體和孕激素受體；鼠痘病毒陰性。 |
| 年齡（性別） | 雄性；11-13日齡 |
| 組織來(lái)源 | 睪丸 |
| 細(xì)胞類型 | 自發(fā)永生化細(xì)胞 |
| 生物安全等級(jí) | BSL-1 |
| 致瘤性 | No, The cells were not tumorigenic in immunosuppressed mice, but did form colonies in semisolid medium. |
| 基因表達(dá)情況 | retinol binding protein, tissue plasminogen activator, transferrin |
| 保藏機(jī)構(gòu) | ATCC; CRL-1715 BCRC; 60254 ECACC; 88111401 |
STR鑒定
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STR位點(diǎn)信息
18-3 18 6-7 12,15 5-5 15 X-1 24,25 1-2 15,17 7-1 24.2,26.2 8-1 16 1-1 15,16 19-2 9 15-3 20.3,21.3,22.3 12-1 20 6-4 18,19 4-2 19.3 3-2 11,14 2-1 9,16 13-1 15.1
11-2 15 17-2 15 -
STR鑒定圖
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參考文獻(xiàn)
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Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice(2021/12/09)
作者：Guoxiang Zhou, Weibo Liu, Limin Dai
期刊：Science Of The Total Environment
DOI：10.1016/j.scitotenv.2021.152247
影響因子 ：10.753
引用產(chǎn)品：CL-0456
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Omega-3 polyunsaturated fatty acids and its metabolite 12-HEPE rescue busulfan disrupted spermatogenesis via target to GPR120(2023/09/24)
作者：Jing Jun, Ouyang Lei, Zhang Hong
期刊：CELL PROLIFERATION
影響因子 ：8.500
引用產(chǎn)品：CL-0456
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Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling(2024/03/12)
作者：Yi Liu, Sijia Chen, Can Ai
期刊：ACTA PHARMACOLOGICA SINICA
DOI：10.1038/s41401-024-01244-5
影響因子 ：8.200
引用產(chǎn)品：CL-0456
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Human placental mesenchymal stem cells ameliorate chemotherapy-induced damage in the testis by reducing apoptosis/oxidative stress and promoting autophagy(2021/03/20)
作者：Jiafeng Lu, Zhenxing Liu, Mingkai Shu
期刊：Stem Cell Research & Therapy
DOI：10.1186/s13287-021-02275-z
影響因子 ：8.079
引用產(chǎn)品：CL-0456
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Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation(2019/07/27)
作者：Bo Ma, Jie Zhang, Zhiming Zhu
期刊：Phytomedicine
DOI：10.1016/j.phymed.2019.153057
影響因子 ：7.900
引用產(chǎn)品：CL-0456
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Toxic effects of Tripterygium glycoside tablets on the reproductive system of male rats by metabolomics, cytotoxicity, and molecular docking(2023/04/10)
作者：Jiachen Ge, Qi Qian, Yanhua Gao
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.154813
影響因子 ：7.900
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The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity(2023/03/07)
作者：Zelin Zhang, Jianyong Cheng, Li Yang
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2023.02.024
影響因子 ：7.400
引用產(chǎn)品：CL-0456
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DDX58 expression promotes inflammation and growth arrest in Sertoli cells by stabilizing p65 mRNA in patients with Sertoli cell-only syndrome(2023/03/22)
作者：Hao Sun, Zhan Yang, Zhihai Teng
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1135753
影響因子 ：7.300
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Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux(2018/10/18)
作者：Guizhu Wu, Ze Zhang, Xue Chen
期刊：Ecotoxicology And Environmental Safety
DOI：10.1016/j.ecoenv.2018.10.013
影響因子 ：6.800
引用產(chǎn)品：CL-0456
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The rare-earth yttrium induces cell apoptosis and autophagy in the male reproductive system through ROS-Ca2+-CamkII/Ampk axis(2023/07/20)
作者：Fangpeng Hou, Junyun Huang, Furong Qing
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115262
影響因子 ：6.800
引用產(chǎn)品：CL-0234 CL-0456 CL-0593 CL-0600 PM150210 PM150312
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Cadmium exposure induces pyroptosis of TM4 cells through oxidative stress damage and inflammasome activation(2024/01/06)
作者：Jinzhao Zhou, Yanwei Zhang, Ling Zeng
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2024.115930
影響因子 ：6.800
引用產(chǎn)品：CL-0456
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Cascading effects of hypobaric hypoxia on the testis: insights from a single-cell RNA sequencing analysis(2023/11/15)
作者：Yunhua Ji, Linmeng Wang, Fuxun Zhang
期刊：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2023.1282119
影響因子 ：5.500
引用產(chǎn)品：CL-0456
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Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity(2022/11/29)
作者：Jingxun Wei, Xuanzhao Lu, Xiaowen Bao
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2022.175430
影響因子 ：5.195
引用產(chǎn)品：CL-0456
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Non-Lethal Concentrations of CdCl2 Cause Marked Alternations in Cellular Stress Responses within Exposed Sertoli Cell Line(2023/02/09)
作者：Yonghong Man, Yunhao Liu, Chuanzhen Xiong
期刊：Toxics
影響因子 ：4.600
引用產(chǎn)品：CL-0456
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A Probiotic Bacillus amyloliquefaciens D-1 Strain Is Responsible for Zearalenone Detoxifying in Coix Semen(2023/11/28)
作者：Tao Deng, Yefei Chen, Jinqiang Zhang
期刊：Toxins
影響因子 ：4.200
引用產(chǎn)品：CL-0456
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Epigenetic programming of TBX2/CX43 mediates lower sperm quality in male offspring induced by prenatal dexamethasone exposure(2023/02/15)
作者：Yi Liu, Yi Liu, Guanghui Chen
期刊：TOXICOLOGICAL SCIENCES
影響因子 ：3.800
引用產(chǎn)品：CL-0456
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Polypyrimidine tract?binding protein 1 regulates the Sertoli cell blood?testis barrier by promoting the expression of tight junction proteins(2021/06/07)
作者：Zhe Yang, Zhi Liu, Yanping Yang
期刊：Experimental and Therapeutic Medicine
影響因子 ：2.700
引用產(chǎn)品：CL-0456
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產(chǎn)品資料
識(shí)別碼示意圖
![LLC [LL/2; LLC1] (小鼠肺癌細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0140-1.jpg)
娜胡文君.png "邱國(guó)娜/胡文君")
.png "梅文強(qiáng)")
