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產(chǎn)品概述
| 名稱 | KGN (人卵巢顆粒細(xì)胞) (STR鑒定正確) |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 成纖維細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | Granulosa cell tumor. Possible to produce progesterone after HCG addition. Cell growth is slow. |
| 年齡（性別） | 女性；69歲 |
| 組織來源 | 卵巢，腹膜 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 卵巢癌細(xì)胞 |
| 生物安全等級 | BSL-1 |
| 倍增時(shí)間 | ~46 hours |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 10,12 D2S1338 25 D3S1358 15,17 D5S818 13 D7S820 11 D8S1179 13,14 D13S317 9 D16S539 10,12 D18S51 12,14 D19S433 13,15.2 D21S11 30,32.2 FGA 25,26 PentaD 10,13 PentaE 12,21 TH01 9 TPOX 8,9 vWA 17 D6S1043 13,20 D12S391 19,21 D2S441 10,12 -
STR鑒定圖
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參考文獻(xiàn)
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Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway(2024/02/21)
作者：Xingyu Zhou, Yunhui Lai, Jun Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06540-w
影響因子 ：9.000
引用產(chǎn)品：CL-0603
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Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN(2024/01/09)
作者：Min Gao, Haofei Shen, Qiuyuan Li
期刊：ENVIRONMENTAL POLLUTION
DOI：10.1016/j.envpol.2024.123333
影響因子 ：8.900
引用產(chǎn)品：CL-0603
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SMAD4-induced knockdown of the antisense long noncoding RNA BRE-AS contributes to granulosa cell apoptosis(2021/05/14)
作者：Wang Yao, Xing Du, Jinbi Zhang
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.05.006
影響因子 ：8.800
引用產(chǎn)品：CL-0603
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The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy(2024/02/24)
作者：Hongwei Duan, Shanshan Yang, Shuai Yang
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155468
影響因子 ：7.900
引用產(chǎn)品：CL-0603
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Berberine alleviates inflammation in polycystic ovary syndrome by inhibiting hyaluronan synthase 2 expression(2024/02/15)
作者：Shaojing He, Hui Li, Qianjie Zhang
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155456
影響因子 ：7.900
引用產(chǎn)品：CL-0603
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Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway(2024/04/05)
作者：Shengjie Liu, Yuanmei Wang, Hanlin Yang
期刊：Stem Cell Research & Therapy
DOI：10.1186/s13287-024-03705-4
影響因子 ：7.500
引用產(chǎn)品：CL-0603
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METTL3 deficiency leads to ovarian insufficiency due to IL-1β overexpression in theca cells(2024/05/31)
作者：Maosheng Cao, Chenfeng Yuan, Xue Chen
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.05.048
影響因子 ：7.400
引用產(chǎn)品：CL-0603
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Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells(2024/04/25)
作者：Wenjie Dai, Bo Xu, Liyang Ding
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.04.229
影響因子 ：7.400
引用產(chǎn)品：CL-0603
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The Release of Peripheral Immune Inflammatory Cytokines Promote an Inflammatory Cascade in PCOS Patients via Altering the Follicular Microenvironment(2021/05/17)
作者：Yishan Liu, Hao Liu, Zitao Li
期刊：Frontiers in Immunology
影響因子 ：7.300
引用產(chǎn)品：CL-0603
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TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo(2024/03/01)
作者：Chong Zhou, Dandan Li, Jinxia He
期刊：Antioxidants
影響因子 ：7.000
引用產(chǎn)品：CL-0603
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A novel perspective on di-hexyl phthalate (2-ethylhexyl)-induced reproductive toxicity in females: Lipopolysaccharide synergizes with mono-2-ethylhexyl ester to cause inflammatory apoptosis rather than autophagy in ovarian granulosa cells(2024/04/13)
作者：Bo Xu, Zhen Zhang, Hong Yang
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2024.116319
影響因子 ：6.800
引用產(chǎn)品：CL-0603
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Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance(2024/01/19)
作者：Mengting Xu, Fang Li, XiaoYan Xu
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2024.115989
影響因子 ：6.800
引用產(chǎn)品：CL-0603
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Exposure to bisphenol A affects transcriptome-wide N6-methyladenine methylation in ovarian granulosa cells(2024/02/13)
作者：Yuxia Zhang, Congcong Yan, Qian Xie
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2024.116071
影響因子 ：6.800
引用產(chǎn)品：CL-0603
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Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice(2023/09/28)
作者：Bo Xu, Tiantian He, Hong Yang
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115534
影響因子 ：6.800
引用產(chǎn)品：CL-0603
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Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice(2022/09/16)
作者：Fang Li, Ying Wang, Mengting Xu
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2022.114093
影響因子 ：6.800
引用產(chǎn)品：CL-0603
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NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes.(2022/12/21)
作者：Ruobing Leng, Yunfang Meng, Xiaomei Sun
期刊：Frontiers in Oncology
影響因子 ：5.738
引用產(chǎn)品：CL-0603
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FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway(2023/09/18)
作者：Lihui Wang, Feiyan Cheng, Rumeng Pan
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.600
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Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome(2021/08/05)
作者：Lihua Sun, Hui Tian, Songguo Xue
期刊：Frontiers in Cell and Developmental Biology
影響因子 ：5.500
引用產(chǎn)品：CL-0603
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Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury(2023/12/05)
作者：Siyuan Wang, Xuqing Li, Jun Li
期刊：CHEMICO-BIOLOGICAL INTERACTIONS
影響因子 ：5.100
引用產(chǎn)品：CL-0603
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MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1(2021/10/21)
作者：Yan Li, Nianling Yao, Yan Gao
期刊：Bioengineered
DOI：10.1080/21655979.2021.1987125
影響因子 ：4.900
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Kurarinone attenuates hydrogen peroxide-induced oxidative stress and apoptosis through activating the PI3K/Akt signaling by upregulating IGF1 expression in human ovarian granulosa cells(2022/09/17)
作者：Weiwei Li, Xiurong Yin, Yani Yan
期刊：ENVIRONMENTAL TOXICOLOGY
影響因子 ：4.500
引用產(chǎn)品：CL-0603
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Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression(2024/04/11)
作者：Rumeng Pan, Rongli Wang, Feiyan Cheng
期刊：Reproductive Biology and Endocrinology
DOI：10.1186/s12958-024-01208-8
影響因子 ：4.400
引用產(chǎn)品：CL-0603
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25(OH)D3 improves granulosa cell proliferation and IVF pregnancy outcomes in patients with endometriosis by increasing G2M+S phase cells(2023/12/05)
作者：Rui Hu, Leilei Li, Lanlan Liang
期刊：Reproductive Biology and Endocrinology
DOI：10.1186/s12958-023-01165-8
影響因子 ：4.400
引用產(chǎn)品：CL-0603
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BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment(2023/10/18)
作者：Ran Gu, Fangfang Dai, Chunrong Xiang
期刊：JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
DOI：10.1016/j.jsbmb.2023.106410
影響因子 ：4.100
引用產(chǎn)品：CL-0603
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Design, synthesis and biological evaluation of rhein–piperazine–furanone hybrids as potential anticancer agents(2024/02/13)
作者：Yu He, Sisi Zhang, Mengxue Wei
期刊：RSC Medicinal Chemistry
影響因子 ：4.100
引用產(chǎn)品：CL-0603
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DNA Methylation Profiles of Ovarian Granular Cells from Fluorosis Female Patients Suffering Reproductive Dysfunctions(2021/10/22)
作者：Biqi He,?Siyuan Dong,?Qun Chen
期刊：Biological Trace Element Research
DOI：10.1007/s12011-021-02954-1
影響因子 ：4.081
引用產(chǎn)品：CL-0603
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Roles of follicle stimulating hormone and sphingosine 1-phosphate co-administered in the process in mouse ovarian vitrification and transplantation(2023/08/24)
作者：Fei Wang, Yuan Tian, Liwen Huang
期刊：Journal of Ovarian Research
DOI：10.1186/s13048-023-01206-1
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway(2024/03/15)
作者：Rongli Wang, Feiyan Cheng, Xinyuan Yang
期刊：Journal of Ovarian Research
DOI：10.1186/s13048-024-01385-5
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway(2024/04/15)
作者：Yuan Zhou, Jinfa Huang, Lingling Zeng
期刊：Journal of Ovarian Research
DOI：10.1186/s13048-024-01403-6
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway(2022/12/30)
作者：Anran Xu, Yuanyuan Fan, Song Liu
期刊：Journal of Ovarian Research
DOI：10.1186/s13048-022-01092-z
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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Exosomes derived from bone marrow mesenchymal stem cells attenuate NLRP3 related pyroptosis in autoimmune premature ovarian insufficiency via NF-κB pathway(2024/01/09)
作者：Jiaxin Xie, Yutao Yang, Aiping Zhuo
期刊：REPRODUCTIVE BIOMEDICINE ONLINE
DOI：10.1016/j.rbmo.2024.103814
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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miR-21-loaded BMSC-derived Exosomes repair ovarian function of autoimmune premature ovarian insufficiency by targeting MSX1(2024/01/09)
作者：Yutao Yang, Lichao Tang, Yuanling Xiao
期刊：REPRODUCTIVE BIOMEDICINE ONLINE
DOI：10.1016/j.rbmo.2024.103815
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo signaling pathway(2024/05/20)
作者：Lijun Wang, Lihui Wang, Rongli Wang
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e31639
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction(2024/05/18)
作者：Hui Chen, Ping Nie, Jingling Li
期刊：Journal of Ovarian Research
DOI：10.1186/s13048-024-01434-z
影響因子 ：4.000
引用產(chǎn)品：CL-0603
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miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E 2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride(2021/01/06)
作者：Qun Chen, Zhen Li, Zhao Xu
期刊：BIOLOGICAL TRACE ELEMENT RESEARCH
DOI：10.1007/s12011-020-02524-x
影響因子 ：3.900
引用產(chǎn)品：CL-0603
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Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2/HO-1 pathway(2023/03/09)
作者：Xin Chen, Qian Lin Song, Ze Hong Li
期刊：Archives Of Biochemistry And Biophysics
影響因子 ：3.900
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Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis(2023/06/05)
作者：Xiaoyuan Xu, Xiaohua Xu, Xiaoshuang Wang
期刊：PHARMACEUTICAL BIOLOGY
DOI：10.1080/13880209.2023.2208636
影響因子 ：3.800
引用產(chǎn)品：CL-0603
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PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro(2023/01/09)
作者：Xiaowei Ji, Yao Ye, Lin Wang
期刊：DRUG DEVELOPMENT RESEARCH
影響因子 ：3.800
引用產(chǎn)品：CL-0603
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Whole exome sequencing reveals novel variants associated with diminished ovarian reserve in young women(2023/03/29)
作者：Na Li, Wanxue Xu, Huimin Liu
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1154067
影響因子 ：3.700
引用產(chǎn)品：CL-0603
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The cytokine profiles in follicular fluid and reproductive outcomes in women with endometriosis(2022/10/26)
作者：Mutian Han, Wei Cheng, Rui Zhu
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影響因子 ：3.600
引用產(chǎn)品：CL-0603
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Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility(2023/09/18)
作者：Xiang Wang, Ruixi Zhou, Xiaowei Lu
期刊：CLINICAL GENETICS
影響因子 ：3.500
引用產(chǎn)品：CL-0603
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Tenascin C activates the toll?like receptor 4/NF?κB signaling pathway to promote the development of polycystic ovary syndrome(2024/04/25)
作者：Han Wu, Mo Yang, Cuiping Yan
期刊：Molecular Medicine Reports
影響因子 ：3.400
引用產(chǎn)品：CL-0603
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Excessive fluoride induces ovarian function impairment by regulating levels of ferroptosis in fluorosis women and ovarian granulosa cells(2024/02/09)
作者：Nan Geng, Siyuan Dong, Pengpeng Xie
期刊：REPRODUCTIVE TOXICOLOGY
DOI：10.1016/j.reprotox.2024.108556
影響因子 ：3.300
引用產(chǎn)品：CL-0603
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SOX4 regulates proliferation and apoptosis of human ovarian granulosa-like tumor cell line KGN through the Hippo pathway(2024/02/27)
作者：Qiang Hong, Mengmeng Fan, Rui Cai
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2024.149738
影響因子 ：3.100
引用產(chǎn)品：CL-0603
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Naringenin mitigates cadmium-induced cell death, oxidative stress, mitochondrial dysfunction, and inflammation in KGN cells by regulating the expression of sirtuin-1(2024/04/22)
作者：Ben Yuan, Junbiao Mao, Junling Wang
期刊：DRUG AND CHEMICAL TOXICOLOGY
DOI：10.1080/01480545.2023.2288798
影響因子 ：2.600
引用產(chǎn)品：CL-0603
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Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway(2023/01/11)
作者：Pingping Sun, Yuemin Zhang, Lilan Sun
期刊：BMC Womens Health
DOI：10.1186/s12905-022-02154-6
影響因子 ：2.500
引用產(chǎn)品：CL-0603
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CircRNA circ_0043533 facilitates cell growth in polycystic ovary syndrome by targeting miR-1179(2022/03/25)
作者：Aixue Chen, Ruiying Jin, Weimei Zho
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2022.100637
影響因子 ：2.100
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KLF4 overexpression facilitates proliferation and represses apoptosis of granulosa cells in polycystic ovary syndrome(2023/06/27)
作者：Hui Miao, Congxiu Miao, Na Li
期刊：Molecular & Cellular Toxicology
DOI：10.1007/s13273-023-00354-1
影響因子 ：1.700
引用產(chǎn)品：CL-0603
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Lycopene mitigates DHT-induced apoptosis and oxidative stress in human granulosa cell line KGN by regulating the Nrf2 pathway(2024/02/05)
作者：Yue Chen, Mengmeng Zhao, Xiaoqing Li
期刊：Molecular & Cellular Toxicology
DOI：10.1007/s13273-023-00419-1
影響因子 ：1.700
引用產(chǎn)品：CL-0603
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Quercetin and tanshinone prevent mitochondria from oxidation and autophagy to inhibit KGN cell apoptosis through the SIRT1/SIRT3-FOXO3a axis(2024/02/29)
作者：Qingzhi Wan, Lisha Tang, Kaili Jin
期刊：CELLULAR AND MOLECULAR BIOLOGY
影響因子 ：1.600
引用產(chǎn)品：CL-0603
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The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission(2022/09/19)
作者：Lihua Sun, Hongjuan Ye, Hui Tian
期刊：Oxidative Medicine and Cellular Longevity
影響因子 ：0.000
引用產(chǎn)品：CL-0603
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產(chǎn)品資料
識別碼示意圖
![MNNG/HOS Cl #5 [R-1059-D] (人骨肉瘤細(xì)胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0492-1-1.jpg)
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