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SiHa (人子宮頸鱗癌細(xì)胞) (STR鑒定正確)
貨號：CL-0210
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價格： ￥1600
生長培養(yǎng)基：MEM（含NEAA）＋10% FBS＋1% P/S
產(chǎn)品概述
| 名稱 | SiHa (人子宮頸鱗癌細(xì)胞) (STR鑒定正確) |
| 別稱 | Siha; SIHA |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | SiHa細(xì)胞是建自一個日本病人的外科手術(shù)的原位組織樣品。電鏡觀察表明，在SiHa細(xì)胞連接處有典型的橋粒，在SiHa細(xì)胞胞質(zhì)中有豐富的張力絲。在裸鼠中，SiHa細(xì)胞能形成低分化的表皮樣癌(Ⅲ級)；SiHa細(xì)胞中，癌基因PRB和p53陽性。 |
| 年齡（性別） | 女性；55歲 |
| 組織來源 | 子宮頸鱗癌 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 宮頸癌細(xì)胞 |
| 生物安全等級 | BSL-2 [Cells contain human papilloma virus] |
| 倍增時間 | ~50-60 hours |
| 致瘤性 | Yes, in nude mice; forms poorly differentiated epidermoid carcinoma (grade III). |
| 基因表達情況 | Oncogenes: p53+; pRB+ |
| 保藏機構(gòu) | ATCC; HTB-35 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 12 D2S1338 24 D3S1358 16,17 D5S818 9 D7S820 10 D8S1179 13,16 D13S317 11 D16S539 12 D18S51 15 D19S433 14.2 D21S11 31 FGA 21 PentaD 9 PentaE 10,12 TH01 6,9 TPOX 8 vWA 14,17 D6S1043 18 D12S391 19,22 D2S441 10 -
STR鑒定圖
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參考文獻
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Gene signatures, immune infiltration, and drug sensitivity based on a comprehensive analysis of m6a RNA methylation regulators in cervical cancer(2022/09/04)
作者：Xiaoqin Lu, Rui Li, Yanqi Ying
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-022-03600-7
影響因子 ：7.400
-
Design of Selective PARP-1 Inhibitors and Antitumor Studies(2024/05/22)
作者：Yiting Zhang, Xiangqian Li, Fang Liu
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c02460
影響因子 ：7.300
引用產(chǎn)品：CL-0210
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Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB(2021/01/19)
作者：Wanyue Wang, Xin Li, Ye Xu
期刊：Cellular Oncology
DOI：10.1007/s13402-020-00582-w
影響因子 ：6.600
-
Prognosis, immune microenvironment, and personalized treatment prediction in Rho GTPase-activating protein 4-mutant cervical cancer: Computer strategies for precision oncology(2023/01/03)
作者：Xiaoqin Lu, Yanqi Ying, Wenyi Zhang
期刊：Life Sciences
影響因子 ：6.100
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Long Intervening Noncoding 00467 RNA Contributes to Tumorigenesis by Acting as a Competing Endogenous RNA against miR-107 in Cervical Cancer Cells(2019/11/01)
作者：Guangcai Li, Li Xin, Yongsheng Wang
期刊：Am J Pathol
DOI：10.1016/j.ajpath.2019.07.012
影響因子 ：6.000
-
Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1(2019/05/23)
作者：Hui Miao, Nuan Wang, Linxin Shi
期刊：Cancer Cell International
影響因子 ：5.800
引用產(chǎn)品：CL-0210
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Synergistic effects of sodium butyrate and cisplatin against cervical carcinoma in vitro and in vivo(2022/10/21)
作者：Huijun Chu, Xiaoyuan Sun, Jia Wang
期刊：Frontiers in Oncology
影響因子 ：5.738
引用產(chǎn)品：CL-0210
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Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor(2022/06/20)
作者：Na Qu, Ruizhe Wang, Yiming Meng
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.108933
影響因子 ：5.714
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3-Hydroxymorindone from Knoxia roxburghii (Spreng.) M. A. Rau induces ROS-mediated mitochondrial dysfunction cervical cancer cells apoptosis via inhibition of PI3K/AKT/NF-κB signaling pathway(2023/03/11)
作者：Xiaojiao Chen, Zhibo Liu, Xue Li
期刊：Journal of Functional Foods
影響因子 ：5.600
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Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway(2023/01/03)
作者：Wei Hu, Yaorui Hu, Yao Pei
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.600
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Methionine enkephalin inhibited cervical cancer migration as well as invasion and activated CD11b+ NCR1+ NKs of tumor microenvironment(2023/09/21)
作者：Na Qu, Yiming Meng, Jingbo Zhai
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110967
影響因子 ：5.600
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The anticancer effect of extract of medicinal mushroom Sanghuangprous vaninii against human cervical cancer cell via endoplasmic reticulum stress-mitochondrial apoptotic pathway(2021/6/17)
作者：Pingya He, Yuhao Hou, Yue Yang
期刊：Journal Of Ethnopharmacology
影響因子 ：5.400
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USF1 regulated circPRDM4 modulates tumorigenesis and immune escape in chemoresistant cervical cancer(2023/09/04)
作者：Yan Zhang, Xing Li, Jun Zhang
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影響因子 ：5.300
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KMT2A regulates cervical cancer cell growth through targeting VDAC1.(2020/05/21)
作者：Changlin Zhang, Yijun Hua, Huijuan Qiu
期刊：Aging-US
影響因子 ：5.200
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CDK6 increases glycolysis and suppresses autophagy by mTORC1-HK2 pathway activation in cervical cancer cells(2022/02/15)
作者：Xiaoxi Zhang, Yunxia Sun, Siyao Cheng
期刊：Cell Cycle
DOI：10.1080/15384101.2022.2039981
影響因子 ：5.173
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Integral membrane protein 2A enhances sensitivity to chemotherapy via notch signaling pathway in cervical cancer(2021/12/07)
作者：Yan Li, Jianhua Wang, Chengzhen Gao
期刊：Bioengineered
DOI：10.1080/21655979.2021.2001218
影響因子 ：4.900
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Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9(2022/04/07)
作者：Caimei Wang, Yiyuan Wang, Congrong Liu
期刊：Bioengineered
DOI：10.1080/21655979.2022.2061144
影響因子 ：4.900
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Lymph node metastasis-related gene signature shows good performance in predicting prognosis and immune infiltration in cervical cancer(2023/06/22)
作者：Yilin Guo, Lu Wang, Zhen Xu
期刊：Frontiers in Oncology
影響因子 ：4.700
引用產(chǎn)品：CL-0210
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The CXCLs-CXCR2 axis modulates the cross-communication between tumor-associated neutrophils and tumor cells in cervical cancer(2024/01/15)
作者：Haizhou Ji, Bin Liu, Mi Ren
期刊：Expert Review of Clinical Immunology
DOI：10.1080/1744666X.2024.2305808
影響因子 ：4.400
引用產(chǎn)品：CL-0210
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Long non-coding RNA LINC00460 promotes proliferation and inhibits apoptosis of cervical cancer cells by targeting microRNA-503-5p(2020/8/1)
作者：Lin Lin, Bing Xin, Tao Jiang
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-020-03853-0.?
影響因子 ：4.300
引用產(chǎn)品：CL-0210
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USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer(2021/11/25)
作者：Zhengliang Li , Xiaojing Liu , Haizhou Yu
期刊：Human Cell
DOI：10.1007/s13577-021-00650-9
影響因子 ：4.300
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OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway(2022/09/29)
作者：Limin Zhou, Hongying Li, Dunlan Zhang
期刊：ONCOLOGY REPORTS
影響因子 ：4.200
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Nocardia rubra cell-wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells(2022/01/07)
作者：Siyang Zhang, Han Wang, Yisi Liu
期刊：Cancer Medicine
影響因子 ：4.000
-
HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression(2024/01/11)
作者：Jianing Zhang, Xiaohui Yu, Yi Guo
期刊：Cancer Medicine
影響因子 ：4.000
引用產(chǎn)品：CL-0210
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APLN promotes the proliferation, migration, and glycolysis of cervical cancer through the PI3K/AKT/mTOR pathway(2024/03/30)
作者：Qi Wang, Bingyu Wang, Wenjing Zhang
期刊：ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
影響因子 ：3.900
引用產(chǎn)品：CL-0210
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Transient receptor potential channels’ genes forecast cervical cancer outcomes and illuminate its impact on tumor cells(2024/05/09)
作者：Shan Jiang, Xuefen Lin, Qiaoling Wu
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2024.1391842
影響因子 ：3.700
引用產(chǎn)品：CL-0210
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Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance(2023/02/03)
作者：Wujiang Lai, Jinrong Liao, Xiaoxuan Li
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1067666
影響因子 ：3.700
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Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein(2023/11/07)
作者：Junying Zhou, Ningjing Lei, Wanjia Tian
期刊：Radiation Oncology
DOI：10.1186/s13014-023-02369-3
影響因子 ：3.600
引用產(chǎn)品：CL-0210
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Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells(2019/11/30)
作者：Rui Tong, Jingru Zhang, Chunyan Wang
期刊：Naunyn-Schmiedebergs Archives of Pharmacology
DOI：10.1007/s00210-019-01772-6
影響因子 ：3.600
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USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination(2024/04/16)
作者：Na Wang, Jing Xu, Yujing Wang
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-024-05710-9
影響因子 ：3.600
引用產(chǎn)品：CL-0210
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hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2(2022/03/11)
作者：Yumei Lv,?Mingyi Wang,?Mingli Chen
期刊：Journal Of Clinical Laboratory Analysis
影響因子 ：3.124
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LINC00460 knockdown sensitizes cervical cancer to cisplatin by downregulating TGFBI(2023/12/28)
作者：Ping Tian, Yuanyuan Feng, Ling Tao
期刊：Chemical Biology & Drug Design
影響因子 ：3.000
引用產(chǎn)品：CL-0210
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Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer(2023/09/16)
作者：Mei Wu, Mingji Ye
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01218-6
影響因子 ：2.900
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Artesunate promotes cervical cancer cell apoptosis by regulating Bcl2 family molecules and reducing the mitochondrial membrane potential(2024/05/14)
作者：Qianying Zhang, Xing Li, Caiyi He
期刊：Oncology Letters
影響因子 ：2.900
引用產(chǎn)品：CL-0210
-
SHCBP1 contributes to the proliferation and self?renewal of cervical cancer cells and activation of the NF?κB signaling pathway through EIF5A(2023/04/21)
作者：Boya Deng, Ailin Li, Ying Zhu
期刊：Oncology Letters
影響因子 ：2.900
-
N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma(2024/04/28)
作者：Qingqing Tian, Juqing Huang, Qin Zhang
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影響因子 ：2.900
引用產(chǎn)品：CL-0210
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FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma(2022/08/28)
作者：Yanru Yang, Yun Zhao, Guorui Sun
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.800
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TRIM21 promotes tumor progression and cancer stemness in cervical squamous cell carcinoma(2023/07/23)
作者：Yanru Yang, Saijie Zuo, Wenqing Li
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.800
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CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways(2022/10/25)
作者：Wenhu Xin, Jian Zhang, Haibin Zhang
期刊：BMC Molecular and Cell Biology
DOI：10.1186/s12860-022-00440-7
影響因子 ：2.800
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ZIC5 promotes aggressiveness and cancer stemness in cervical squamous cell carcinoma(2022/12/05)
作者：Qingge Jia, Junyang Song, Tianqi Xu
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.800
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Mesencephalic astrocyte-derived neurotrophic factor inhibits cervical cancer progression via regulating macrophage phenotype(2024/05/12)
作者：Miaomiao Huang, Jingjing Hu, Yueran Chen
期刊：MOLECULAR BIOLOGY REPORTS
DOI：10.1007/s11033-024-09602-6
影響因子 ：2.800
引用產(chǎn)品：CL-0210
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Relevance research between the expression of p16INK4a, Notch1, and hTERC genes: The development of HPV16‐positive cervical cancer(2020/1/24)
作者：Wenyan Huo, Shuaiyu Zhai, Yanbo Wang
期刊：Journal Of Clinical Laboratory Analysis
影響因子 ：2.700
引用產(chǎn)品：CL-0210
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Circular RNA circ_0000119 promotes cervical cancer cell growth and migration via miR-433-3p/PAK2 axis(2023/08/04)
作者：Junxiao Zhang, Guanghua Chu, Lihua Zheng
期刊：JOURNAL OF APPLIED GENETICS
DOI：10.1007/s13353-023-00772-w
影響因子 ：2.400
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Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer(2023/11/24)
作者：Jiaxin Liu, Lu Tang, Wenzhu Chu
期刊：BIOCHEMICAL GENETICS
DOI：10.1007/s10528-023-10568-6
影響因子 ：2.400
引用產(chǎn)品：CL-0210
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Circular RNA circVPRBP serves as a microRNA-106b-5p sponge to regulate proliferation and metastasis of cervical cancer cells via tripartite motif-containing protein 3(2022/08/10)
作者：Yingying Jiang, Wei Xu, Junzhen Tao
期刊：ANTI-CANCER DRUGS
DOI：10.1097/CAD.0000000000001335
影響因子 ：2.300
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PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway(2023/01/05)
作者：Boya Deng, Siyang Zhang, Yingying Zhou
期刊：HISTOCHEMISTRY AND CELL BIOLOGY
DOI：10.1007/s00418-022-02175-0
影響因子 ：2.300
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HIV gp120/Tat protein-induced epithelial–mesenchymal transition promotes the progression of cervical lesions(2023/11/19)
作者：Peizhi Wang, Baojun Yang, Huang Huang
期刊：AIDS Research and Therapy
DOI：10.1186/s12981-023-00577-1
影響因子 ：2.200
引用產(chǎn)品：CL-0210
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LncRNA Opa interacting protein 5-antisense RNA 1 (OIP5-AS1) promotes the migration, invasion and epithelial-mesenchymal transition (EMT) through targeting miR-147a/insulin-like growth factor 1 receptor (IGF1R) pathway in cervical cancer tissues and c(2022/03/01)
作者：Limei Zhang, Yufei Cai, Chenchen Tian
期刊：Journal Of Obstetrics And Gynaecology Research
影響因子 ：1.600
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