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產(chǎn)品概述
| 名稱 | PANC-1 (人胰腺癌細(xì)胞) (STR鑒定正確) |
| 別稱 | Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P |
| 種屬 | 人 |
| 生長(zhǎng)特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | 這株人胰腺癌細(xì)胞株P(guān)ANC-1源自于胰腺癌導(dǎo)管細(xì)胞。PANC-1細(xì)胞倍增時(shí)間為52小時(shí)，G6PD活性處于低泳動(dòng)性的B型。染色體研究表明，PANC-1細(xì)胞模式數(shù)目為63，包括3個(gè)獨(dú)特標(biāo)記的染色體和1個(gè)小環(huán)狀染色體。PANC-1細(xì)胞的生長(zhǎng)可被1U/ml的左旋天冬酰胺酶抑制；PANC-1細(xì)胞能在軟瓊脂上生長(zhǎng)，亦能在裸鼠上成瘤。 |
| 年齡（性別） | 男性；56歲 |
| 組織來(lái)源 | 胰腺；胰管；上皮細(xì)胞癌 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 胰腺癌細(xì)胞 |
| 生物安全等級(jí) | BSL-1 |
| 倍增時(shí)間 | ~38-56 hours |
| 保藏機(jī)構(gòu) | ATCC; CRL-1469 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 10,12 D2S1338 23,24 D3S1358 17 D5S818 11,13 D7S820 8,10 D8S1179 14,15 D13S317 11 D16S539 11,12 D18S51 12 D19S433 11,16 D21S11 28 FGA 21 PentaD 14 PentaE 7,14 TH01 7,8 TPOX 8,11 vWA 15 D6S1043 11,12 D12S391 22 D2S441 10,14 -
STR鑒定圖
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參考文獻(xiàn)
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TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC(2024/03/12)
作者：Wenjie Huang, Xiaojun Hu, Xiang He
期刊：DRUG RESISTANCE UPDATES
DOI：10.1016/j.drup.2024.101079
影響因子 ：24.300
引用產(chǎn)品：CL-0184
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Dual-crosslinking immunostimulatory hydrogel synchronously suppresses pancreatic fistula and pancreatic cancer relapse post-resection(2023/12/24)
作者：Ruizhi Zhao, Qiuqun Xiao, Yuanyuan Wu
期刊：BIOMATERIALS
DOI：10.1016/j.biomaterials.2023.122453
影響因子 ：14.000
引用產(chǎn)品：CL-0184
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ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway(2022/04/07)
作者：Ma Zuyi, Li Zhenchong, Wang Shujie
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02310-8
影響因子 ：11.300
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Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription(2022/02/18)
作者：Weiwei Yang , Jing Li, Minghui Zhang
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-022-02260-1
影響因子 ：11.300
引用產(chǎn)品：CL-0016 CL-0041 CL-0097 CL-0101 CL-0114 CL-0184 CL-0215 CL-0525
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SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis(2021/07/24)
作者：Dianyun Ren, Yan Sun, Dan Zhang
期刊：Cancer Letters
DOI：10.1016/j.canlet.2021.07.035
影響因子 ：9.700
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Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma(2024/02/26)
作者：Yanqin Tan, Bowen Sun, Xi Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06551-7
影響因子 ：9.000
引用產(chǎn)品：CL-0184
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METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation(2023/03/28)
作者：Chengjie Lin, Ting Li, Yan Wang
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05715-1
影響因子 ：9.000
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HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells(2024/03/16)
作者：Ziyang Luo, Qingfang Zheng, Shazhou Ye
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06592-y
影響因子 ：9.000
引用產(chǎn)品：CL-0184
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Local Sustained Chemotherapy of Pancreatic Cancer Using Endoscopic Ultrasound-Guided Injection of Biodegradable Thermo-Sensitive Hydrogel(2023/07/19)
作者：Dan Yang, Jing Ning, Xiaomin Liao
期刊：International Journal of Nanomedicine
影響因子 ：8.000
引用產(chǎn)品：CL-0184
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Diterpenoid honatisine overcomes temozolomide resistance in glioblastoma by inducing mitonuclear protein imbalance through disruption of TFAM-mediated mtDNA transcription(2023/12/29)
作者：Zongyang Li, Ke Sai, Guoxu Ma
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.155328
影響因子 ：7.900
引用產(chǎn)品：CL-0184
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Simultaneous Fluorescence Visualization of Epithelial-Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial-Mesenchymal Transition on Drug Efficacy(2018/09/18)
作者：Mingming Luan, Jinjie Chang, Wei Pan
期刊：Analytical Chemistry
DOI：10.1021/acs.analchem.8b02494
影響因子 ：7.400
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System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma(2022/10/05)
作者：Cheng Yan, Yandie Niu, Feng Li
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-022-03632-z
影響因子 ：7.400
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Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5′-UTR RNA G-Quadruplexes(2024/01/25)
作者：Maolin Li, Letian Dai, Zhuoyu Gao
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c01773
影響因子 ：7.300
引用產(chǎn)品：CL-0184
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Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2(2024/01/26)
作者：Hao Yang, Zhongyi Li, Shiqi Zhu
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2024.1347683
影響因子 ：7.300
引用產(chǎn)品：CL-0184
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Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: new sights to clinical decision-making(2023/03/07)
作者：Jun Zhu, Yanlong Shi, Sheng Lan
期刊：APOPTOSIS
DOI：10.1007/s10495-023-01823-7
影響因子 ：7.200
引用產(chǎn)品：CL-0184
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CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10(2024/05/06)
作者：Demin Kong, Yingying Wu, Binghua Tong
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2024.167214
影響因子 ：6.200
引用產(chǎn)品：CL-0184
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Anti?silencing function 1B promotes the progression of pancreatic cancer by activating c?Myc(2022/11/17)
作者：Min Zhang, Luyang Zhang, Minghe Zhou
期刊：INTERNATIONAL JOURNAL OF ONCOLOGY
影響因子 ：5.884
引用產(chǎn)品：CL-0184
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Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2(2022/09/20)
作者：Meijie Chen, Xuena Li, Bulin Du
期刊：BIOCHEMICAL PHARMACOLOGY
影響因子 ：5.800
引用產(chǎn)品：CL-0027 CL-0042 CL-0059 CL-0184 CL-0448 CL-0627 CM-0059 CM-0448A
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PARP1 controls the transcription of CD24 by ADP-ribosylating the RNA helicase DDX5 in pancreatic cancer(2022/12/28)
作者：Kang Chen, Manxiong Dai, Quanneng Luo
期刊：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
DOI：10.1016/j.biocel.2022.106358
影響因子 ：5.652
引用產(chǎn)品：CL-0184
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Deciphering the action mechanism of paeoniflorin in suppressing pancreatic cancer: A network pharmacology study and experimental validation.(2022/10/20)
作者：Chunhao Cao, Wenting Zhao, Xianglin Chen
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2022.1032282
影響因子 ：5.600
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The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis(2023/06/20)
作者：Weimin Hu, Siqing Liu, Kongfan Zhu
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110505
影響因子 ：5.600
引用產(chǎn)品：CL-0184
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LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4(2024/03/19)
作者：Zhenchong Li, Zuyi Ma, Shujie Wang
期刊：Biology Direct
DOI：10.1186/s13062-024-00463-4
影響因子 ：5.500
引用產(chǎn)品：CL-0184
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5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis(2023/10/12)
作者：Wenpeng Cao, Zhirui Zeng, Shan Lei
期刊：Biomolecules
影響因子 ：5.500
引用產(chǎn)品：CL-0184
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Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes proliferation and mobility of pancreatic cancer through AXIN2(2023/07/24)
作者：Wenpeng Cao, Shisi Dai, Wanyuan Ruan
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影響因子 ：5.300
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COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation(2023/02/26)
作者：Yao Song, Lei Wang, Kaidong Wang
期刊：Cancers
影響因子 ：5.200
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Identifying endoplasmic reticulum stress-related molecular subtypes and prognostic model for predicting the immune landscape and therapy response in pancreatic cancer(2023/10/09)
作者：Biao Zhang, Xu Chen, Zhizhou Wang
期刊：Aging-US
影響因子 ：5.200
引用產(chǎn)品：CL-0184
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MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells(2024/02/29)
作者：Wuming Liu, Yifan Ren, Tao Wang
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2024.176462
影響因子 ：5.000
引用產(chǎn)品：CL-0184
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A gold–selenium-bonded nanoprobe for real-time in situ imaging of the upstream and downstream relationship between uPA and MMP-9 in cancer cells(2019/03/16)
作者：Mingming Luan
期刊：Chem Commun
影響因子 ：4.900
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A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation(2021/11/22)
作者：Chao Wu, Zhihong Huang, Ziqi Meng
期刊：Chinese Medicine
DOI：10.1186/s13020-021-00534-y
影響因子 ：4.900
引用產(chǎn)品：CL-0184
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Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research(2022/01/08)
作者：Zhenghai Bai, Fangshi Xu, Xiaodan Feng
期刊：Bioengineered
DOI：10.1080/21655979.2021.2019873
影響因子 ：4.900
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Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments(2023/01/14)
作者：Haojia Wang, Zhishan Wu, Xiaotian Fan
期刊：Chinese Medicine
DOI：10.1186/s13020-023-00710-2
影響因子 ：4.900
引用產(chǎn)品：CL-0184
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Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer(2023/10/24)
作者：Xu Chen, Qihang Yuan, Hewen Guan
期刊：Frontiers in Oncology
影響因子 ：4.700
引用產(chǎn)品：CL-0184
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Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis(2021/11/19)
作者：Yuan Chi, He Xin, Zhaoyu Liu
期刊：Frontiers in Oncology
影響因子 ：4.700
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MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation(2020/01/21)
作者：Wenjie Huang, Jianyou Gu, Tian Tao
期刊：Frontiers in Oncology
影響因子 ：4.700
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PANoptosis-related molecular subtype and prognostic model associated with the immune microenvironment and individualized therapy in pancreatic cancer(2023/07/14)
作者：Biao Zhang, Bingqian Huang, Xiaonan Zhang
期刊：Frontiers in Oncology
影響因子 ：4.700
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Effects of anoxic prognostic model on immune microenvironment in pancreatic cancer(2023/06/05)
作者：Yangdong Wu, Qingyan Kou, Lin Sun
期刊：Scientific Reports
DOI：10.1038/s41598-023-36413-9
影響因子 ：4.600
引用產(chǎn)品：CL-0184
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Identification by genetic algorithm optimized back propagation artificial neural network and validation of a four-gene signature for diagnosis and prognosis of pancreatic cancer(2022/11/09)
作者：Zhenchong Li, Zuyi Ma, Qi Zhou, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Zhongshi Wu, Jinglin Zhao, Shanzhou Huang, Chuanzhao Zhang, Baohua Hou
期刊：Heliyon
DOI：10.1016/j.heliyon.2022.e11321
影響因子 ：4.000
引用產(chǎn)品：CL-0184
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GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma(2022/06/05)
作者：Xiaoyuan Sun, Huijun Chu, Ke Lei
期刊：PANCREATOLOGY
影響因子 ：3.977
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Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis(2023/10/30)
作者：Zemin Zhu, Bo Yi, Zikai Tang
期刊：BMC CANCER
DOI：10.1186/s12885-023-11557-z
影響因子 ：3.800
引用產(chǎn)品：CL-0184
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TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation(2021/2/19)
作者：Yuanbo Cui, Chunyan Zhang, Shanshan Ma
期刊：Biological Chemistry
影響因子 ：3.700
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ITGB6 promotes pancreatic fibrosis and aggravates the malignant process of pancreatic cancer via JAK2/STAT3 signaling pathway(2024/02/28)
作者：Yu Zhang, Zhiyuan Chen, Zhengchao Shen
期刊：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
DOI：10.1007/s00210-024-03003-z
影響因子 ：3.600
引用產(chǎn)品：CL-0184
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Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway(2020/3/10)
作者：Xiangpeng Meng, Jia Ma, Baosheng Wang
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-020-00734-4
影響因子 ：3.400
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Circadian Genes MBOAT2/CDA/LPCAT2/B4GALT5 in the Metabolic Pathway Serve as New Biomarkers of PACA Prognosis and Immune Infiltration(2023/04/30)
作者：Qingqing Wang, Shuning Zhou, Xinyi Hu
期刊：Life-Basel
影響因子 ：3.200
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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization(2024/04/15)
作者：Xuanzeng Pei, Min Cai, Dawei Jiang
期刊：World Journal of Gastrointestinal Oncology
影響因子 ：3.000
引用產(chǎn)品：CL-0184
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Transcriptome analysis of pancreatic cancer cell response to treatment with grape seed proanthocyanidins(2018/12/6)
作者：Weihua Wang, Leilei Zhan, Dongqi Guo
期刊：Oncology Letters
影響因子 ：2.900
引用產(chǎn)品：CL-0184
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Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum(2020/11/12)
作者：Xiao Wu, Liping Jiang, Zeng Zhang
期刊：Oncology Letters
影響因子 ：2.900
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A prospective prognostic signature for pancreatic adenocarcinoma based on ubiquitination-related mRNA-lncRNA with experimental validation in vitro and vivo(2023/08/04)
作者：Zhizhou Wang, Qihang Yuan, Xu Chen
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01158-1
影響因子 ：2.900
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Grape seed proanthocyanidins inhibit proliferation of pancreatic cancer cells by modulating microRNA expression(2019/1/4)
作者：Weihua Wang, Leilei Zhan, Dongqi Guo
期刊：Oncology Letters
影響因子 ：2.900
引用產(chǎn)品：CL-0184
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Targeting the EZH2-PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic Cancer(2021/7/22)
作者：Jilong Hu, Zhinan Zheng, Jia Lei
期刊：PPAR Research
影響因子 ：2.900
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Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer(2023/02/12)
作者：Jiaxing Du, Yongsheng Chen, Genglong Liu
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.800
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GPX3 represses pancreatic cancer cell proliferation, migration and invasion, and improves their chemo?sensitivity by regulating the JNK/c?Jun signaling pathway(2024/01/29)
作者：Ye Ma, Lixing Zhang, Xin Gao
期刊：Experimental and Therapeutic Medicine
影響因子 ：2.700
引用產(chǎn)品：CL-0184
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Construction and validation of a m6A RNA methylation and ferroptosis-related prognostic model for pancreatic cancer by integrated bioinformatics analysis.(2022/10/01)
作者：Tong Wu, Tianyang Qian, Renjie Lin
期刊：Journal of Gastrointestinal Oncology
影響因子 ：2.587
引用產(chǎn)品：CL-0184
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Identification of a Pyroptosis-Related Gene Signature and Effect of Silencing the CHMP4C and CASP4 in Pancreatic Adenocarcinoma(2022/11/14)
作者：Yajun Chen, Yiming Liu, Menghao Wang
期刊：International Journal of General Medicine
影響因子 ：2.145
引用產(chǎn)品：CL-0184
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Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells(2020/5/20)
作者：Lei Zhang, Zhenyong Wang, Deshuai Kong
期刊：Bioscience Biotechnology And Biochemistry
DOI：10.1080/09168451.2020.1762479
影響因子 ：1.600
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