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產(chǎn)品概述
| 名稱 | U-937 (人組織細(xì)胞淋巴瘤細(xì)胞) (STR鑒定正確) |
| 別稱 | U937; U 937 |
| 種屬 | 人 |
| 生長(zhǎng)特性 | 懸浮細(xì)胞 |
| 細(xì)胞形態(tài) | 單核細(xì)胞 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 3×10^5-5×10^5cells/mL |
| 推薦換液頻率 | 2-3次/周 |
| 注意事項(xiàng) | 該細(xì)胞為懸浮細(xì)胞，請(qǐng)注意離心收集細(xì)胞懸液；請(qǐng)勿直接倒掉細(xì)胞培養(yǎng)液。 |
| 背景描述 | U-937細(xì)胞是由Sundstrom和Nilsson于1974年建立，取材于患組織細(xì)胞淋巴瘤病人的胸水。研究表明：U-937細(xì)胞能被人混合淋巴細(xì)胞培養(yǎng)上清，佛波脂、維生素D3、γ干擾素、腫瘤壞死因子和維甲酸誘導(dǎo)終末單核細(xì)胞分化。U-937細(xì)胞免疫球蛋白產(chǎn)物和EB病毒表達(dá)為陰性；U-937細(xì)胞表達(dá)Fas抗原且對(duì)TNF和抗-Fas抗體敏感。 |
| 年齡（性別） | 男性 |
| 組織來(lái)源 | 組織細(xì)胞淋巴瘤 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 淋巴瘤細(xì)胞 |
| 生物安全等級(jí) | BSL-1 |
| 倍增時(shí)間 | ~30-60 hours |
| 受體表達(dá)情況 | complement (C3) |
| 基因表達(dá)情況 | lysozyme; beta-2-microglobulin (beta 2 microglobulin); tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid (PMA) |
| 保藏機(jī)構(gòu) | ATCC; CRL-1593ATCC; CRL-1593.2 DSMZ; ACC-5 ECACC; 85011440 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 12 D2S1338 17,20 D3S1358 16 D5S818 12 D7S820 9,11 D8S1179 12,13 D13S317 10,12 D16S539 12 D18S51 13,14 D19S433 14,16 D21S11 27,29 FGA 22,25 PentaD 12,13 PentaE 13 TH01 6,9.3 TPOX 8,11 vWA 14,15 D6S1043 12,18 D12S391 17,18 D2S441 10 -
STR鑒定圖
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參考文獻(xiàn)
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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues(2024/02/15)
作者：Jian Wu, Chaoye Wang, Shuhui Sun
期刊：Protein & Cell
影響因子 ：21.100
引用產(chǎn)品：CL-0239
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An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy(2020/08/20)
作者：Hui Wang, Qian Xu, Chanyuan Zhao
期刊：Journal for ImmunoTherapy of Cancer
影響因子 ：10.900
引用產(chǎn)品：CL-0239
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miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis(2023/11/16)
作者：Yunhui Jia, Lianping Cheng, Jiaxuan Yang
期刊：ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
DOI：10.1161/ATVBAHA.123.319776
影響因子 ：8.700
引用產(chǎn)品：CL-0239
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Label-free, rapid and highly accurate identification and categorization of leukemia cells via Raman spectroscopy(2023/08/22)
作者：Luyue Jiang, Matthew Xinhu Ren, Gang Niu, Jingang Shi, Xinhao Cao, Yan Duan, Heping Wu, Zhen Xie, Yi Quan, Libo Zhao, Zhuangde Jiang, Yihong Gong, Wei Ren, Gang Zhao
期刊：SENSORS AND ACTUATORS B-CHEMICAL
影響因子 ：8.400
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Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway(2022/10/18)
作者：Hanyue Li, Yu Yuan, Hongying Chen
期刊：Molecular Metabolism
DOI：10.1016/j.molmet.2022.101617
影響因子 ：8.100
引用產(chǎn)品：CL-0239
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Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy(2024/03/09)
作者：Ruiqi Jiang, Bin Xu, Shumeng Zhi
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2024.116304
影響因子 ：6.700
引用產(chǎn)品：CL-0239
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RAB3D/MDM2/β-catenin/c-MYC axis exacerbates the malignant behaviors of acute myeloid leukemia cells in vitro and in vivo(2022/10/24)
作者：Jian Liu, Yumiao Mai, Yingjie Wang
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00549-z
影響因子 ：5.854
引用產(chǎn)品：CL-0239
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High-glucose conditions attenuate the response of macrophages to Legionella pneumophila infection by inhibiting NOD1 and MAPK signaling(2024/05/15)
作者：Yuting Zhang, Sicong Liang, Ze Deng
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.112254
影響因子 ：5.600
引用產(chǎn)品：CL-0239
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Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation(2022/09/07)
作者：Peng Liu, Shuya Wang, Guangxin Wang
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影響因子 ：5.300
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miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population(2018/11/29)
作者：Suli Huang, Ziquan Lv, Ying Wen
期刊：Journal Of Cellular And Molecular Medicine
影響因子 ：5.300
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Discovery of novel 5-phenylpyrazol receptor interacting protein 1(RIP1) kinase inhibitors as anti-necroptosis agents by combining virtual screening and in vitro and in vivo experimental evaluations(2023/11/11)
作者：Ying Shi, Jiaqin Tang, Shumeng Zhi
期刊：BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2023.106964
影響因子 ：5.100
引用產(chǎn)品：CL-0239
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MicroRNA-124a contributes to glucocorticoid resistance in acute-on-chronic liver failure by negatively regulating glucocorticoid receptor alpha(2019/10/01)
作者：Xin Wang, Hongrui Xu, Yadong Wang
期刊：Annals of Hepatology
DOI：10.1016/j.aohep.2019.08.007
影響因子 ：3.800
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Identification of Blood Let-7e-5p as a Biomarker for Ischemic Stroke(2016/10/24)
作者：Suli Huang, Ziquan Lv, Yi Guo
期刊：PLoS One
DOI：10.1371/journal.pone.0163951
影響因子 ：3.700
引用產(chǎn)品：CL-0239
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Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells: hsa_circ_0013880/USP32/Rap1b in acute myeloid leukemia(2023/03/23)
作者：Heyang Zhang, Yuan Tao, Xin Ding
期刊：ACTA BIOCHIMICA ET BIOPHYSICA SINICA
影響因子 ：3.700
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Matrisome provides a supportive microenvironment for oral squamous cell carcinoma progression(2021/12/16)
作者：Yungang He, Pingmeng Deng, Ying Yan
期刊：Journal of Proteomics
DOI：10.1016/j.jprot.2021.104454
影響因子 ：3.300
引用產(chǎn)品：CL-0239
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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization(2024/04/15)
作者：Xuanzeng Pei, Min Cai, Dawei Jiang
期刊：World Journal of Gastrointestinal Oncology
影響因子 ：3.000
引用產(chǎn)品：CL-0239
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Gastrodin Suppresses the Progression of Atherosclerosis and Vascular Inflammation by Regulating TLR4/NF‐κB Pathway(2024/01/25)
作者：Bing Dai, Cunfa Liu, Song Zhang
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01218-8
影響因子 ：2.600
引用產(chǎn)品：CL-0239
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Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2(2024/04/10)
作者：Guofu Li, Ziyu Xiong, Ying Li
期刊：Discover Oncology
DOI：10.1007/s12672-024-00963-9
影響因子 ：2.200
引用產(chǎn)品：CL-0239
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Calycosin Induces Ferroptosis by SLC7A11 Through the PI3K/Akt Pathway in Acute Myelocytic Leukemia(2024/03/04)
作者：Chaoping Xu, Wei Chang, Hui Jiang
期刊：Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
DOI：10.1007/s43450-023-00502-7
影響因子 ：1.600
引用產(chǎn)品：CL-0239
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Human EVI2B acts as a Janus-faced oncogene/antioncogene by differently affecting as per cancer type neoplastic cells growth and immune infiltration:(2023/03/23)
作者：Fangyingnan Zhang, Xinning Wang, Xiaoqi Zhang
期刊：Oncologie
DOI：10.1515/oncologie-2022-1002
影響因子 ：0.900
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