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產(chǎn)品概述
| 名稱 | 22RV1 (人前列腺癌細胞) (STR鑒定正確) |
| 別稱 | 22RV1; 22Rv-1; 22rV1; CWR22-Rv1; CWR22R-V1; CWR22-R1; CWR22Rv1; CWR22R |
| 種屬 | 人 |
| 生長特性 | 貼壁細胞 |
| 細胞形態(tài) | 上皮細胞樣 |
| 凍存條件 | 凍存液：90%FBS+10%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 注意事項 | 22RV1細胞復(fù)蘇時需要離心去除DMSO。凍存細胞復(fù)蘇最初階段，貼壁量少，成簇松散貼壁，但是最終細胞會變平并且擴散成很好的單層，這個過程需要4-5天時間。細胞生長緩慢，細胞只能生長到90%的匯合度。細胞凍存后復(fù)蘇成活率不高，推薦凍存液配比為90%FBS+10% DMSO，使用優(yōu)質(zhì)血清。 |
| 背景描述 | 22RV1是來自異種移植(在閹割引起前列腺癌衰退又在其父親的雄性激素信賴型CWR22嫁接后復(fù)發(fā)的小鼠中連續(xù)傳代)的人前列腺癌上皮細胞系；22RV1細胞系表達前列腺特異抗原。二羥基睪丸脂酮輕微刺激22RV1細胞生長，經(jīng)Western Blot檢測溶解產(chǎn)物與抗雄性激素受體抗體起免疫反應(yīng)；EGF刺激22RV1細胞生長，但TGFβ-1不能抑制細胞生長；22RV1可在裸鼠中成瘤。 |
| 年齡（性別） | 男性 |
| 組織來源 | 前列腺 |
| 細胞類型 | 腫瘤細胞 |
| 腫瘤類型 | 前列腺癌細胞 |
| 生物安全等級 | BSL-2 |
| 倍增時間 | ~40 hours |
| 致瘤性 | Yes, forms tumors in nude mice. |
| 受體表達情況 | androgen receptor |
| 保藏機構(gòu) | ATCC; CRL-2505 BCRC; 60545 DSMZ; ACC-438 |
STR鑒定
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STR位點信息
Amelogenin X,Y CSF1PO 10,11 D2S1338 17,18 D3S1358 15 D5S818 11,13 D7S820 9,10,11 D8S1179 13,14 D13S317 9,12 D16S539 12 D18S51 13,14 D19S433 13,14 D21S11 30 FGA 19,23 PentaD 9,12 PentaE 5,13 TH01 6,9.3 TPOX 8 vWA 15,21 D6S1043 16 D12S391 18,25 D2S441 11,12 -
STR鑒定圖
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參考文獻
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Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer(2024/03/21)
作者：Da Ren, Wei Li, Ruijiang Zeng
期刊：CELL DEATH AND DIFFERENTIATION
DOI：10.1038/s41418-024-01282-w
影響因子 ：12.400
引用產(chǎn)品：CL-0004
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Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer(2022/09/01)
作者：Shidong Lv, Zeyu Wu, Mayao Luo
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-05182-0
影響因子 ：9.000
-
Tautomycin and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer(2022/11/29)
作者：Luo, Mayao, Zhang, Yifan, Xu, Zhuofan, Wu, Chenwei, Ye, Yuedian, Liu, Rui, Lv, Shidong, Wei, Qiang
期刊：Cell Death Discovery
DOI：10.1038/s41420-022-01257-1
影響因子 ：7.000
-
Synthesis and bioactivity evaluation of ferrocene-based hydroxamic acids as selective histone deacetylase 6 inhibitors(2022/12/07)
作者：Jiangkun Yan, Kairui Yue, Xuejing Fan
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2022.115004
影響因子 ：6.700
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AID-induced CXCL12 upregulation enhances castration-resistant prostate cancer cell metastasis by stabilizing β-catenin expression(2023/11/23)
作者：Qi Li, Jinfeng Fan, Zhiyan Zhou
期刊：iScience
DOI：10.1016/j.isci.2023.108523
影響因子 ：5.800
引用產(chǎn)品：CL-0004
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A Liquid–Liquid Phase Separation-Related Index Associate with Biochemical Recurrence and Tumor Immune Environment of Prostate Cancer Patients(2023/03/14)
作者：Qi You, Jiayin Chen, Xiaohui Wu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.600
-
LOC100996425 acts as a promoter in prostate cancer by mediating hepatocyte nuclear factor 4A and the AMPK/mTOR pathway(2021/08/19)
作者：Xiuyan Wang, Bin Song, Mingcui Zang
期刊：Journal Of Cellular And Molecular Medicine
影響因子 ：5.300
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MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways(2021/11/10)
作者：Sihai Zhou,?Zhihong Dai,?Liang Wang
期刊：Journal Of Cellular And Molecular Medicine
影響因子 ：5.295
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177Lu-Labeled Bivalent Ligands of Prostate-Specific Membrane Antigen for Endoradiotherapy of Prostate Cancer(2023/12/28)
作者：Ruoxue Dai, Zhikai Cai, Rui Hu
期刊：MOLECULAR PHARMACEUTICS
DOI：10.1021/acs.molpharmaceut.3c00987
影響因子 ：4.900
引用產(chǎn)品：CL-0004
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YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation(2024/03/09)
作者：Xuefeng Zhao, Suli Lv, Neng Li
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影響因子 ：4.800
引用產(chǎn)品：CL-0004
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Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer(2023/08/16)
作者：Hongzhuang Wen, Changbao Qu, Zhu Wang
期刊：FASEB JOURNAL
影響因子 ：4.800
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Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression(2022/10/17)
作者：Anning Zhao, Zhan Yang, Dandan Wang
期刊：FASEB JOURNAL
影響因子 ：4.800
引用產(chǎn)品：CL-0004
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USF1-mediated ALKBH5 stabilizes FLII mRNA in an m6A-YTHDF2-dependent manner to repress glycolytic activity in prostate adenocarcinoma(2023/07/26)
作者：Dewang Fu, Qingyue Si, Chenxi Yu
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23609
影響因子 ：4.600
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Epigenetic activation of METTL14 promotes docetaxel resistance in prostate cancer by promoting pri-microRNA-129 maturation(2024/03/28)
作者：Cheng Wu, Chunqing Miao, Songlin Zhou
期刊：ENVIRONMENTAL TOXICOLOGY
影響因子 ：4.500
引用產(chǎn)品：CL-0004
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HMGB1 promotes the development of castration?resistant prostate cancer by regulating androgen receptor activation(2022/09/19)
作者：Junyu Chen, Duo Xu, Taiwei Wang
期刊：ONCOLOGY REPORTS
影響因子 ：4.200
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Crafting a Personalized Prognostic Model for Malignant Prostate Cancer Patients Using Risk Gene Signatures Discovered through TCGA-PRAD Mining, Machine Learning, and Single-Cell RNA-Sequencing(2023/06/07)
作者：Feng Lyu, Xianshu Gao, Mingwei Ma
期刊：Diagnostics
DOI：10.3390/diagnostics13121997
影響因子 ：3.600
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IU1 and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer(2023/08/07)
作者：Yifan Zhang, Yuanpeng Liao, Mayao Luo
期刊：PROSTATE
影響因子 ：2.800
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GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer(2022/10/25)
作者：Ming Yang, Xudong Zhu, Yang Shen
期刊：PeerJ
影響因子 ：2.700
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Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer(2023/04/12)
作者：Qingfu Zhang, Peng Zhang, Zhongting Zhao
期刊：PeerJ
影響因子 ：2.700
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Circular RNA Dipeptidyl Peptidase 4 (circDPP4) Stimulates the Expression of Glutamate Dehydrogenase 1 to Contribute to the Malignant Phenotypes of Prostate Cancer by Sponging miR-497-5p(2023/04/20)
作者：Long Pei, Xiaosen Song, Xiangdong Liang
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-023-00750-x
影響因子 ：2.600
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A morpholine derivative N-(4-morpholinomethylene)ethanesulfonamide induces ferroptosis in tumor cells by targeting NRF2(2024/01/30)
作者：Bingchun Sun, Ligang Zhang, Binhua Wu
期刊：BIOLOGICAL & PHARMACEUTICAL BULLETIN
影響因子 ：2.000
引用產(chǎn)品：CL-0004
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Synthesis of curcumin derivatives for suppression of castration-resistant prostate cancer(2024/02/06)
作者：Shunze Gong, Chixiang Yuan, Hang Hu
期刊：JOURNAL OF CHEMICAL RESEARCH
影響因子 ：1.400
引用產(chǎn)品：CL-0004
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