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產(chǎn)品概述
| 名稱 | HCC1937 (人乳腺癌細(xì)胞) (STR鑒定正確) |
| 別稱 | HCC-1937 |
| 種屬 | 人 |
| 生長(zhǎng)特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | HCC1937細(xì)胞1995年10月13日最初來(lái)源于原發(fā)性導(dǎo)管癌，用了11.5個(gè)月建株。腫瘤分類為TNMⅡB期，3級(jí)。BRCA1分析表明，HCC1937細(xì)胞是BRCA 15382C突變純合的，而來(lái)源于同一病人的類淋巴母細(xì)胞細(xì)胞株在這個(gè)突變位點(diǎn)上是雜合的。另兩個(gè)家庭成員也有這個(gè)突變；一個(gè)同卵雙生姐妹也患有乳腺癌。HCC1937細(xì)胞有一個(gè)后天的Tp53突變，而其野生型等位基因丟失；一個(gè)PTEN基因的后天的純合缺失，以及多個(gè)與乳腺癌發(fā)病機(jī)理相關(guān)的位點(diǎn)上發(fā)生的雜合突變。HCC1937細(xì)胞Her2-neu和p53表達(dá)都呈陰性。HCC1937細(xì)胞的上皮細(xì)胞特異性標(biāo)志上皮細(xì)胞糖蛋2(EGP2)和細(xì)胞角蛋白19都呈陽(yáng)性；雌激素受體(ER)和孕酮(PR)表達(dá)陰性。 |
| 年齡（性別） | 女性；23歲 |
| 組織來(lái)源 | 乳房；原發(fā)性導(dǎo)管癌；3級(jí)，ⅡB期 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 乳腺癌細(xì)胞 |
| 生物安全等級(jí) | BSL-1 |
| 倍增時(shí)間 | ~50-60 hours |
| 受體表達(dá)情況 | estrogen receptor, negative;progesterone receptor, negative |
| 基因表達(dá)情況 | Epithelial glycoprotein 2 (EGP2); cytokeratin 19 |
| 保藏機(jī)構(gòu) | ATCC; CRL-2336 DSMZ; ACC-513 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 12 D2S1338 25 D3S1358 18 D5S818 12 D7S820 9,10 D8S1179 12,13 D13S317 13 D16S539 13,14 D18S51 12 D19S433 14,15 D21S11 28 FGA 20,22 PentaD 9 PentaE 13 TH01 6 TPOX 11 vWA 16,17 D6S1043 11 D12S391 17.3,21 D2S441 10 -
STR鑒定圖
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參考文獻(xiàn)
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PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis(2023/06/01)
作者：Zhe Wang, Ruolei Li, Niuniu Ho
期刊：Journal for ImmunoTherapy of Cancer
影響因子 ：10.900
引用產(chǎn)品：CL-0007 CL-0041 CL-0093 CL-0149 CL-0211 CL-0228 CL-0525 CM-0007 CM-0041 CM-0093 CM-0149 CM-0211 CM-0228 CM-0525
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Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-α signaling axis in triple-negative breast cancer(2024/01/24)
作者：Chenying Liu, Xiaolong Qian, Chunyan Yu
期刊：CANCER LETTERS
DOI：10.1016/j.canlet.2024.216642
影響因子 ：9.700
引用產(chǎn)品：CL-0093
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Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer(2024/01/10)
作者：Yanqin Tan, Hui Guo, Shuwei Zhang
期刊：npj Precision Oncology
DOI：10.1038/s41698-023-00489-3
影響因子 ：7.900
引用產(chǎn)品：CL-0093
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Oxypalmatin regulates proliferation and apoptosis of breast cancer cells by inhibiting PI3K/AKT signaling and its efficacy against breast cancer organoids(2023/03/10)
作者：Xian Lin, Dong Chen, Xinyu Chu
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.154752
影響因子 ：7.900
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Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis(2023/06/09)
作者：Kailiang Wu, Weidong Li, Hanjiao Liu
期刊：AMERICAN JOURNAL OF PATHOLOGY
DOI：10.1016/j.ajpath.2023.05.010
影響因子 ：6.000
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Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer(2023/10/27)
作者：Keying Liang, Qian Wang, Li Qiu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.600
引用產(chǎn)品：CL-0093
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Leveraging senescence-oxidative stress co-relation to predict prognosis and drug sensitivity in breast invasive carcinoma(2023/08/04)
作者：Yinghui Ye, Yulou Luo, Tong Guo, Chenguang Zhang, Yutian Sun, Anping Xu, Ling Ji, Jianghua Ou, Shang Ying Wu
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2023.1179050
影響因子 ：5.200
引用產(chǎn)品：CL-0093 CL-0149 CL-0324 CL-0726 CM-0093 CM-0149 CM-0324 CM-0726
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Triple-Negative Breast Cancer Intrinsic FTSJ1 Favors Tumor Progression and Attenuates CD8+ T Cell Infiltration(2024/01/31)
作者：Yangqing Sun, Qingqing Liu, Shangwei Zhong
期刊：Cancers
影響因子 ：5.200
引用產(chǎn)品：CL-0093
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Constructing a novel prognostic model for triple-negative breast cancer based on genes associated with vasculogenic mimicry(2024/05/08)
作者：Yu Ren, Luyi Feng, Zhihua Tan
期刊：Aging-US
影響因子 ：5.200
引用產(chǎn)品：CL-0093
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LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability(2021/11/05)
作者：Pengping Li, Rongguo Li, Yuqing Huang
期刊：Aging-US
影響因子 ：5.200
引用產(chǎn)品：CL-0093
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Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint(2021/11/08)
作者：Meiran Chu, Xinglan An, Daoyu Zhang
期刊：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
DOI：10.1016/j.bbamcr.2021.119169
影響因子 ：5.100
引用產(chǎn)品：CL-0093
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Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors(2024/04/04)
作者：Jialin Zhang, Gengshen Yin, Chunmiao Ye
期刊：Chinese Journal of Cancer Research
DOI：10.21147/j.issn.1000-9604.2024.02.03
影響因子 ：5.100
引用產(chǎn)品：CL-0093
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The dePARylase NUDT16 promotes radiation resistance of cancer cells by blocking SETD3 for degradation via reversing its ADP-ribosylation(2024/01/22)
作者：Weijun Wu, Wenjing Wu, Yingshi Zhou
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影響因子 ：4.800
引用產(chǎn)品：CL-0093
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Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway(2020/10/30)
作者：Daoyu Zhang, Xinglan An, Qi Li
期刊：Frontiers in Oncology
影響因子 ：4.700
引用產(chǎn)品：CL-0093
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Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines(2024/03/21)
作者：Lijie Zhu, Binzhuo Liu, Feng Jin
期刊：MOLECULES
影響因子 ：4.600
引用產(chǎn)品：CL-0093
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Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells(2023/12/08)
作者：Ming Lei, Yunlong Zhang, Fengying Huang
期刊：Scientific Reports
DOI：10.1038/s41598-023-49136-8
影響因子 ：4.600
引用產(chǎn)品：CL-0093
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Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis(2023/02/06)
作者：Jiacheng Li, Xiaozhen Liu, Lin Chen
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116415
影響因子 ：3.800
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RAMP2-AS1 inhibits CXCL11 expression to suppress malignant phenotype of breast cancer by recruiting DNMT1 and DNMT3B(2022/04/04)
作者：Li Li, Yaping Gan, Hui Peng
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2022.113139
影響因子 ：3.700
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Prognosis stratification of patients with breast invasive carcinoma based on cysteine metabolism-disulfidptosis affinity(2023/07/08)
作者：Yuting Zhang, Yinghui Ye, Anping Xu
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-023-05028-y
影響因子 ：3.600
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