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產品概述
| 名稱 | T-47D (人乳腺管癌細胞) (STR鑒定正確) |
| 別稱 | T-47-D; T47-D; T47D:A; T47D |
| 種屬 | 人 |
| 生長特性 | 貼壁細胞 |
| 細胞形態(tài) | 上皮細胞樣 |
| 凍存條件 | 凍存液：55% 基礎培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | T-47細胞分離自一位54歲乳房侵入性導管癌的女性患者胸水；發(fā)現(xiàn)分化的上皮亞株(T-47D)有細胞質連接和17-β-雌二醇及其他類固醇降血鈣素的受體，T-47D細胞表達WNT7B癌基因。 |
| 年齡（性別） | 女性；54歲 |
| 組織來源 | 乳腺；乳房；導管；來自導管癌肋膜滲出液轉移灶 |
| 細胞類型 | 腫瘤細胞 |
| 腫瘤類型 | 乳腺癌細胞 |
| 生物安全等級 | BSL-1 |
| 倍增時間 | ~36-46 hours |
| 致瘤性 | Yes, forms colonies in soft agar. |
| 受體表達情況 | calcitonin, expressed; androgen receptor, expressed; estrogen receptor, expressed; progesterone receptor, expressed; glucocorticoid receptor, positive, expressed; prolactin, expressed; calcitonin; androgen receptor, positive; progesterone receptor, p |
| 保藏機構 | ATCC; HTB-133 DSMZ; ACC-739 ECACC; 85102201 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 11,13 D2S1338 24 D3S1358 15,17 D5S818 12 D7S820 11 D8S1179 13 D13S317 12 D16S539 10 D18S51 17 D19S433 14 D21S11 28,31 FGA 23 PentaD 10,11,12 PentaE 7,14 TH01 6 TPOX 11 vWA 14 D6S1043 19 D12S391 19 D2S441 14 -
STR鑒定圖
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參考文獻
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作者：Zhe Wang, Ruolei Li, Niuniu Ho
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Cadmium promotes breast cancer cell proliferation, migration and invasion by inhibiting ACSS2/ATG5-mediated autophagy(2021/01/15)
作者：Yidan Liang, Huifeng Pi, Lingzhi Liao
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DOI：10.1016/j.envpol.2021.116504
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Galangin attenuates doxorubicin-induced cardiotoxicity via activating nuclear factor erythroid 2-related factor 2/heme oxygenase 1 signaling pathway to suppress oxidative stress and inflammation(2023/09/01)
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影響因子 ：7.200
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作者：Yang Yue, Ping Deng, Heng Xiao
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DOI：10.1016/j.ecoenv.2021.112626
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MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway(2024/05/09)
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